Endocrine Abstracts

Background: Alstrom syndrome is a rare autosomal recessive genetic disorder characterised by vision loss, hearing loss, childhood obesity, insulin resistance and hyperinsulinemia, type 2 diabetes, hypertriglyceridemia, cardiomyopathy, and progressive pulmonary, hepatic, and renal dysfunction. Hyperinsulinemia develops early, and pancreatic islets show beta-cell proliferation, thus suggesting that both insulin resistance and increased insulin secretion might contribute to gluco...

Background: Although high levels of calcitonin suggest neoplastic proliferations such as medullary thyroid carcinoma, C cell hyperplasia and some neuroendocrine tumors, systemic diseases and drugs may also elevate calcitonin. Although calcitonin is not as effective as PTH, it has got a role in calcium hemoastasis. Supraphysiological calcitonin level can lead to hypocalcemia.Case presentation: A 57-year-old male patient was diagnosed with epilepsy with co...

Introduction and aims: Mean platelet volume (MPV) is a newly indicator of platelet activation which was associated with atherosclerosis. There are limited studies in the literature about MPV levels in patients with both hypoparathyroidism and hyperparathyroidism. This preliminary study, we aimed to investigate a relationship with MPV and serum PTH and calcium levels in patients with disorder of calcium metabolism.Materials and methods: Fourty-nine hyperp...

Introduction: Hyperthyroidism is defined as thyroid hyperfunction due to overproduction of thyroid hormones. Graves disease is the most common cause of hyperthyroidism. Hyperthyroidism may be associated with glycemic dysregulation. We are presenting a case with diabetic ketoacidosis who had Graves disease and acute appendicitis.Case presentation: A nineteen years old female patient wtih Graves disease who had hyperthyroidism despite high dose antithyroid...

Introduction and aims: Triggering receptor expressed on myeloid cells 1 (TREM-1) is secreted by macrophage and neutrophils in adipose tissue to released pro-inflammatory chemokines and cytokines. TREM-1 activate Janus kinase 2 (JAK2), protein kinase B (PKB/AKT) and extracellular signal related kinase (ERK1/2) pathways and upregulate the expression of genes involved in the inflammatory response. We aimed to indicate associations with serum TREM-1 levels, total sulfhydryl (SH) a...

Introduction: Mucormycosis is a serious fungal infection, It is frequently observed in immunocompromised patients such as diabetes mellitus. The most common clinical presentation of mucormycosis is rhino-orbita- cerebral infection.Case presentation: A seventy three-years- old man with diabetes mellitus who was operated due to orbital trauma a mounth ago. Periorbital cellulitis and diabetic ketosis developed during post-operative period and the patient wa...

IntroductionPituitary apoplexy is seen in 1.5–27.7% of pituitary adenomas. Common etiologies include hypertension, diabetes mellitus, radiotherapy, contrast-enhanced MR, surgery, drugs, anticoagulant, antithrombotic, estrogen, head trauma and pregnancy. SARS-CoV-2 had spread rapidly, and caused COVID-19 pandemic. Although it mainly causes respiratory problems, there may also be extrapulmonary involvement. COVID-19 infection is associated with hemorr...

Aim: İmpaired glucose tolerance and hyperinsulinism/insulin resistance frequently accompany by acromegaly. NLO (Neutrophile lymphocyte ratio) is demonstrated as a simple indicator of systemic inflammation and it is also known that NLO is associated with atherosclerosis progression in coronary artery and a risk factor in coroner artery disease. In this study, we intend to search the association between both coronary atherosclerosis seen frequently in patients diagnosed wi...

Aim: 402 patients who were admitted and FNA was done in the Endocrinology Clinic at EBEAH were enrolled in this study. 340 (85%) of them were females and 62 (15%) of them were males. The age range was between 16 and 82. There weren’t any statistical differences in age between both sexes. Thyroid cancer is reported to constitute <2% of cancers in humans. At the same time, it is the most lethal endocrine malignancy. In the literature it is stated that 3% of all cancers ...

The pathologist cannot easily decide some thyroid fine-needle aspiration biopsy (FNA) into the benign, suspicious, or malignity and this condition are reported as ‘atypia of undetermined significance’ (AUS) or ‘follicular lesion of undetermined significance’ in the Bethesda system. Diagnosis of AUS of a thyroid nodule is leaved an endocrinologist as well as the patients in a difficult situation. However, the risk of malignancy at AUS is ~5–15%. Our aim...